Grape is produced originally in the caribbean area,and Asia Minor, planted in the warm areas of the northern hemisphere, especially in Europe and the south of Middle Asia. Proanthocyanidins in grape seed exeract is thiry to fifty times as effective as Vitamin C and Vitamin E with regard to anti-oxidation and that it can pass through the screen in blood and brain within the human body smoothly and protect the brain and neurosystem effecaciously, exterminating free radicals obviously, improving blood circulation, decreasing the blood viscosity and inhibiting heart disease and other illness. Besides, It can maintain the elasticity and water of the skin, delaying the appearance of the wrinkles.