Antioxidant
S. grosvenori extract and the cucurbitane glycosides mogroside IV, mogroside V, 11-oxo-mogroside V, and siamenoside I inhibited copper-mediated, low-density, lipoprotein and cell-mediated, low-density lipoprotein oxidation in a dose-dependent fashion, with 11-oxo-mogroside V as the most active component. The antioxidant, free?\radical scavenging activities of the extract and 11-oxo-mogroside V were less than those of vitamin E in the same in vivo study.

Antineoplastic
In vitro and animal studies suggest potential cancer chemopreventive activities of cucurbitane glycosides and related compounds from the fruit of luo han guo. An ethanol extract of S. grosvenori was evaluated for its effect on Epstein-Barr virus-early antigen (EBV-EA) activation as a method of detecting chemoprotective activity. The extract inhibited activation of EBV-EA at a level similar to or greater than the activity of beta-carotene.In a similar study, 11-oxo-mogroside V and mogroside V showed strong inhibitory effects. A 2-stage skin carcinogenesis model in mice ingesting mogroside V or 11-oxomogroside V showed delayed development and reduced numbers of papillomas at 10 and 15 weeks, respectively, compared with control group animals. Inhibitory effects of mogroside V and 11-oxo-mogroside V on another skin carcinogenesis model in mice using peroxynitrite also showed a reduction in numbers of papillomas formed and delayed papilloma development.

Antihistaminic
The effect of luo han guo extract and its glycosides on allergic symptoms in mice were studied. No effect on skin scratching behavior or nasal rubbing was noted following single doses of 300 and 1,000 mg/kg, respectively, of the extract or the glycosides.Repeated daily doses of 300 and 1,000 mg/kg/day between 2 and 4 weeks of the extract and the glycosides showed gradual inhibition of nasal rubbing and skin scratching.
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