Hypericum perforatum extract UV 0.3%,China HuiX price supplier

Hypericum perforatum UV 0.3%

The introduction for Hypericum perforatum

Product description

Hyperforin (HP) is an abundant component of St John's wort with antibiotic and antidepressive activity. We report here the ability of HP and that of polyphenolic procyanidin B2 (PB-2) to inhibit the growth of leukemia K562 and U937 cells, brain glioblastoma cells LN229 and normal human astrocytes. HP inhibited the growth of cells in vitro with GI ₅₀ values between 14.9 and 19.9 μM. The growth inhibitory effect of PB-2 was more pronounced in leukemia cell lines K562 and U937, the GI ₅₀ concentrations being about 12.5 μM established after 48 h incubation differed significantly ( P <0.05) from those of LN229 and normal human astrocytes (103.1 and 96.7 μM), respectively. Further, HP and hypericin (HY) (a naphthodianthrone from St John's wort) acted synergistically in their inhibitory effect on leukemic (K562, U937) cell growth. Cell death occurred after 24 h treatment with HP and PB-2 by apoptosis. A dose-dependent loss of membrane phospholipid asymmetry associated with apoptosis was induced in all cell lines as evidenced by the externalization of phosphatidylserine (PS) and morphological changes in cell size and granulosity by scatter characteristics. In leukemia U937 cells, HP increased the activity of caspase-9 and caspase-3 and in K562 cells caspase-8 and caspase-3. In addition, the broad spectrum caspase inhibitor z-VAD-fmk inhibited both the appearance of PS exposure and the activation of caspases, illustrating the functional relevance of caspase activation during HP-induced apoptosis. Cytocidal effects of HP and its cooperation with HY on tumor growth inhibition in a synergistic manner make the St John's wort an interesting option in cancer warranting further in vitro and in vivo investigation.

Benefits:

Hyperforin a constituent of St John's wort ( Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines.

•   Depression treatment,

•  anti-bacteria,

• pre-menstrual period syndrome cure,

• seasonal depression treatment.

Application:

1, St. John's Wort extract hypericin can e nhanc e the effect of neurotransmitters in the brain.

2, St. John's Wort extract hypericin has the function of a nti-depressive and sedative properties.

3, St. John's Wort extract hypericin can i mprove capillary circulation and i ncreases cardiac circulation .

4, St. John's Wort extract hypericin is a valuable healing and anti-inflammatory remedy, also can improve

tolerance to stress.

5, St. John's Wort extract hypericin is e ffective remedy for the nervous system, relaxing tension, and anxiety

and lifting the spirits.

6, As a tissue restorative for nerves,St. John's Wort extract hypericin is indicated for stroke patients,

for mild neuroses, sleepwalkers, and accident victims.

7, St. John's Wort extract hypericin has significant support in the treatment of mild to moderate depression,

can also help to control appetite and p romote weight loss.

Package and Storage

1.Packing Detail

Packed in 40cm*50cm paper-drums and two plastic-bags inside.

2.Net Weight

3.Shelf Life

two years under well Storage situation and stored away from direct sun light.

4.Storage Situation

About more:

Strict research and inspection:

Packing detail:

ABOUT US:

We, Hunan Huixin Biotech Inc., are professional botanical/ herbal/ Plant Extract manufacturer and exporter in China. Focused on the identification, development and production of active ingredients from plants or herbs,we specialized in producting and marketing of botanical/herbal/plant extracts. Established in 2012, we have sucessfully researched many products such as Huperzine A, red clover extract, ganlanthamine hydrobromide, Green coffee bean extract etc, and we have been certified by ISO9002, Kosher, Halal. Producted with perfect marketing network,advanced technology and excellent management, we make sure the product quality! Up to now, after years of accumulation of international trade experience and customer resources, Huixin has established good brand image, solid customer base and sales and services network in the field of plant extracts. And our products are popular over 40 countries in Europe, America, Southeast Asian and Afirica due to its excellent quality and competitive price. To promote technical innovation and adapt to market development, We shall work for the health of human and the realization of traditional Chinese herb medicine in worldwide by scientific, modern coorperation management. “Better you by nature” is our striving motto, and we will do the best to provide you a better healthy life with our competitive product!