1. Product Name: Vitamin B12; Cyanocobalamin
2. CAS No.: 13115-03-2
3. Molecular Formula: C63H88CoN14O14P-
4. Molecular Weight: 1354.36
5. Chemical Structural Formula:
Introduction:
Vitamin B12 is a general term for vitamin B group chemicals with a cobalt ring structure. There are four types of vitamin B12 family: cyanocobalamin, hydroxocobalamin, adenosylcobalamin and methylcobalamin, but clinically used vitamin B12 usually refers to cyanocobalamin.
Cyanocobalamin and hydroxocobalamin have no direct biological activity. Cyanocobalamin is a prodrug, which can be converted into methylcobalamin and adenosylcobalamin in the human body. Methylcobalamin and adenosylcobalamin are the two active coenzyme forms of vitamin B12 in the human body.
Cyanocobalamin and hydroxocobalamin are dark red crystals or crystalline powder; adenosylcobalamin is yellow-orange hexagonal crystals, which turn dark red when exposed to air; methylcobalamin is bright red needle-like crystals or crystalline powder.
All four injections of cobalamin are red. In the storage of ordinary medicines, it is necessary to keep them away from sunlight. Cyanocobalamin is the most stable one, and generally it will not be degraded by sunlight; adenosylcobalamin and methylcobalamin are unstable when exposed to sunlight, and must be strictly protected from sunlight, and the injection time must also be shortened.
The four cobalamins can prevent and treat red blood cell anemia and treat peripheral neuropathy. In the human body, we can only use adenosylcobalamin and methylcobalamin directly, cyanocobalamin and hydroxocobalamin need to be converted into adenosylcobalamin and methylcobalamin by the organelles in the liver before they can be utilized by the human body. For people with liver diseases, such as hepatitis and cirrhosis, adenosylcobalamin and methylcobalamin should be directly supplemented to reduce the burden on the liver, and patients with liver function impairment can be given priority.
Specifications:
| Test Items | Specifications | Test Methods |
| Characteristics |
Dark red, crystalline powder or dark red crystals |
Ph. Eur. Monograph:0547 Visual method |
| Identification A |
1) UV: Absorption maxima at 278nm, 361nm and 547-559nm 2) A361nm/A278nm: 1.70~1.90 |
Ph. Eur. Monograph/Ph.Eur.<2.2.25> |
| Identification B |
UHPLC: The principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution(c). |
Ph. Eur. Monograph/Ph.Eur.<2.2.29> |
| Loss on Drying |
≤10.0% |
Ph. Eur. Monograph/Ph.Eur.<2.2.32> |
| Assay |
97.0%~102.0% |
Ph. Eur. Monograph/Ph.Eur.<2.2.25> |
| Related Substances |
1) Total impurities≤3.0%; 2) 7β, 8β-Lactone-cyanocobalamin≤0.7%; 3) 50-Carboxycyanocobalamin≤0.5%; 4) 34-Methylcyanocobalamin≤1.5%; 5) 32-Carboxycyanocobalamin≤0.5%; 6) 8-Epi-cyanocobalamin≤0.5%; 7) Impurity F≤0.5%; 8) Unspecified impurities≤0.2% |
Ph. Eur. Monograph/Ph.Eur.<2.2.29>(UHPLC) |
| Acetone |
≤5000ppm |
In house/(GC) |
| The total aerobic microbial count |
≤1000cfu/g |
ChP 2020 |
| The total combined yeasts/mould count |
≤100cfu/g |
ChP 2020 |
Package: 100g/tin or 1kg/tin, carton box outside.
Storage Conditions: Preserved in unopened original containers in a cool dry place before using; kept away from sunlight, heat and moisture.
Shelf Life: 60 months if stored under above conditions.
Dalian Handom Chemicals Co., Ltd(HDC CHEM). is a professional supplier & exporter for Nutritional Ingredients and Food Additives from China.
Originally HDC CHEM has been supplying food grade Vitamin C, Vitamin E and Folic Acid to our customers in South America and Africa, then the business grew and customers looked forward to buying more and diversified products from us, and considered HDC CHEM as a reliable sourcing partner in China. Over time, our business was expanded to other countries or markets like USA, Canada, Europe and Middle East.
HDC CHEM has long-lasting business relationships with more than 50 leading manufacturers in China.
Our Founder Mr. John Wang has rich experience in chemical production, global trading and industry trends. We not only have a professional technical background, but also a vision of enthusiastic service to customers. Sincerely hope that we can have the honor to establish good partnerships with you.
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